Determination of Renal Hypothermic Temperature Adequacy for Renoprotection During Ischemia Using Renal Interstitial Glycerol Concentrations in a Porcine Model

Renal hypothermia decreases the rate of cellular release of glycerol into the interstitial fluid. Hypothermia at 25°C doubles the time required for renal interstitial glycerol to accumulate to levels associated with irreparable renal function damage. Therefore, relatively warmer hypothermic temperatures may be sufficient to extend a significant renoprotective effect during ischemia.