Article ID Journal Published Year Pages File Type
3908764 The Breast 2012 7 Pages PDF
Abstract

ObjectiveTo determine the accuracy of telomerase activity in predicting a higher risk for breast cancer.Study designA quantitative systematic review was performed. Studies that detected telomerase activities in breast tissue were included.ResultsTwenty-five primary studies were analyzed, which included 2395 breast lesions. The proportion of breast cancer was 60.8%. Eighty-two percent (1193/1455) of breast cancer cases and 18% (169/940) of benign lesions cases were positive for telomerase activity. For breast cancer vs benign or normal breast tissue, the pooled likelihood ratio for the presence of telomerase activity was 4.5 (95% confidence interval [CI], 3.1–6.5) and the post-test probability was 88% (95% CI, 83–91). For breast cancer vs benign or normal tissue, the area under the summary receiver operating characteristic (SROC) curve was 0.89 with the Q* point value of 0.82.ConclusionOur systematic review showed that telomerase activity was significantly present in breast cancer when compared with normal breast tissue or benign breast lesions.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
Authors
, , , , , , , , ,