Maternal thyrotrophin in euthyroid women is related to meconium stained amniotic fluid in women who deliver at or over 41 weeks of gestation

BackgroundMaternal thyroid dysfunction is of known influence on pregnancies in the preterm period. However little is known about its effect on term and post term pregnancies. Meconium stained amniotic fluid (MSAF) is known to occur preferentially in (post)term pregnancies.AimsTo assess a possible independent relation between maternal thyroid function and MSAF.Study design and subjects1051 women, in whom thyroid function was assessed at each trimester, were followed prospectively (delivery ≥ 37 weeks). We compared the difference in mean TSH and FT4 between women with (152) and without (899) MSAF using one way ANOVA. Thyroid function was assessed in subgroups regarding gestational age. Finally we performed multiple logistic regression analysis with MSAF as dependent variable and TSH as independent variable adjusting for various confounders.ResultsMaternal thyroid function was not associated with the incidence of MSAF when analysing all deliveries ≥ 37 weeks. However, in the “at-risk” group for MSAF (> 41 weeks), multiple logistic regression showed an independent relation between MSAF and TSH (O.R.: 1.61, 95% CI: 1.10–2.43).ConclusionsThe present study shows that in women delivering ≥ 41 weeks of gestation, higher TSH is independently related to MSAF.