Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3917467 | Early Human Development | 2011 | 4 Pages |
Invasive fungal infections (IFIs) constitute an important cause for morbidity and mortality in immunocompromised pediatric patients [1]. Despite substantial achievements, the prevention and treatment of IFIs are still limited by the facts that not all antifungal agents are approved in the pediatric population, the appropriate dosage of these drugs has not been established for all age groups, and postmarketing data providing information on the safety and efficacy of approved agents under real-life circumstances are scant. In this article, we 1) briefly review the principles of drug development, 2) discuss safety and approved indications of antifungal agents, and 3) provide a summary of current options for treatment of invasive fungal infections in pediatric patient populations.