Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3920336 | European Journal of Obstetrics & Gynecology and Reproductive Biology | 2012 | 4 Pages |
ObjectiveThe objective of this prospective randomised study was to evaluate if there is an improvement in clinical outcomes when assisted hatching (AH) is performed in embryos derived from vitrified/warmed oocytes in an ovum donation programme using egg cryobanking.Study designSixty oocyte recipients in a donation programme using egg cryobanking were randomly allocated to the assisted hatched (AH, n = 30) or control group (n = 30). The pregnancy and implantation rates were compared between the groups.ResultsA total of 288 vitrified oocytes were warmed for the 60 recipients. Of the 288 vitrified oocytes, 94.8% survived. All surviving oocytes were sperm injected, and 83.5% underwent fertilisation. There were 172 good-quality embryos selected for transfer. The total pregnancy rate was 40%. The pregnancy rate did not differ between the AH and control groups (43.3% and 33.3%, respectively, p = 0.1967), but AH resulted in a higher implantation rate (31.6% vs. 18.4%, p = 0.0206).ConclusionOur study demonstrates the effectiveness of AH in embryos derived from warmed oocytes. Our results also suggest that oocyte cryopreservation can be considered as a tool for providing highly successful outcomes in an egg donor programme.