Article ID Journal Published Year Pages File Type
3920766 European Journal of Obstetrics & Gynecology and Reproductive Biology 2010 5 Pages PDF
Abstract

ObjectiveTo investigate whether the PI3KCA and AKT1 gene influences the risk of developing endometriosis in South Indian women.Study designMutations in exon 9 and 20 of PI3KCA gene and E17K mutation in exon 4 of AKT1 gene were tested for association in a case–control study between eutopic and ectopic endometrium tissue from 30 endometriosis cases and eutopic endometrium tissue from 30 controls. The genotype frequencies of these mutations were compared using polymerase chain reaction and direct sequencing analysis of tissue DNA.ResultsThe analysis did not reveal any activating somatic mutations in either PI3KCA or AKT1 gene in the cases.ConclusionIn the present study we could not observe any mutation in PI3KCA and AKT1 gene, indicating that these mutations are rarely associated with endometriosis in South Indian women.

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Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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