Article ID Journal Published Year Pages File Type
3921101 European Journal of Obstetrics & Gynecology and Reproductive Biology 2010 5 Pages PDF
Abstract

ObjectiveTo describe pregnancy outcomes for pregnant women with sickle cell disease (SCD) receiving prophylactic transfusions.Study designThis retrospective case–control study compared pregnancy outcomes among women with SCD receiving prophylactic transfusions and women without any hemoglobinopathy, matched for ethnicity, parity, age and hospital.ResultsThe study included two groups of pregnancies: 128 in women with SCD (95 with SS phenotype and 33 with SC) and 128 in women with AA phenotype. No woman died. Two perinatal deaths (2.1%) and five alloimmunizations (5.3%) occurred, all in the SS group. Compared with the control group, HbSS disease was more often associated with pre-eclampsia (9.4% versus 2.3%, p = .03), preterm delivery (15.8% versus 6.2%, p = .01), birth weight <10th percentile (13.7% versus 3.9%, p = .008) and caesarean delivery (73.6% versus 26.4%, p < .01).ConclusionDespite prophylactic blood transfusions, SCD remains a severe complicating factor in pregnancy. The policy of systematic transfusions should be analyzed in a sufficiently large randomized trial.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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