The effect of adenosine 5′-triphosphate on calcium mobilization and cell proliferation in cervical cancer cells

ObjectiveTo know the effect of adenosine 5′-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.Study designFour different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.ResultsExtracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-κB in all cell lines used.ConclusionThese results suggest that calcium mobilization and NF-κB dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.