| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3922446 | European Journal of Obstetrics & Gynecology and Reproductive Biology | 2007 | 5 Pages |
ObjectiveThe objective was to investigate the relationship between insulin resistance and increased serum homocysteine in women with polycystic ovarian syndrome (PCOS).DesignProspective controlled trial.SettingDepartment of Obstetrics & Gynecology, Mansoura Faculty of Medicine, Mansoura, Egypt.PatientsNinety PCOS women as a study group and 35 women with infertility due to other causes as a control group.Outcome measuresSerum homocysteine levels in the presence and absence of insulin resistance in PCOS patients.ResultsHomocysteine levels were significantly higher in PCOS patients than in the controls. Considering 11 μmol/l as the cut-off level for a normal homocysteine level, 41.1% of PCOS patients (37 out of 90) and 2.9% of control group (1 out of 35) had high homocysteine levels. With regard to insulin resistance, 23% of PCOS patients without insulin resistance (9 out of 39) had a high homocysteine level, while 47% of PCOS patients with insulin resistance (24 out of 51) had this, thus demonstrating the effect of insulin resistance on the homocysteine level.ConclusionThere is a strong association between serum homocysteine and insulin resistance in women with PCOS that contributes to the long-term complications of PCOS.
