Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3924544 | European Urology | 2015 | 8 Pages |
BackgroundHigh-risk prostate cancer (PCa) is an extremely heterogeneous disease. A clear definition of prognostic subgroups is mandatory.ObjectiveTo develop a pretreatment prognostic model for PCa-specific survival (PCSS) in high-risk PCa based on combinations of unfavorable risk factors.Design, setting, and participantsWe conducted a retrospective multicenter cohort study including 1360 consecutive patients with high-risk PCa treated at eight European high-volume centers.InterventionRetropubic radical prostatectomy with pelvic lymphadenectomy.Outcome measurements and statistical analysisTwo Cox multivariable regression models were constructed to predict PCSS as a function of dichotomization of clinical stage (