| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3932193 | Fertility and Sterility | 2011 | 12 Pages |
Abstract
We report the first quantitative assessment of DNA methylation for any gene in the human preimplantation embryo to reveal that imprints exist at KvDMR1, RB1, SNRPN, and GRB10 in the human blastocyst. For comparison, in two human embryonic stem cell lines, imprints were also observed at KvDMR1, SNRPN, GRB10, and other imprinted loci, whereas RB1 and MEG3 were hypermethylated.
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Authors
John Ph.D., Kathryn Ph.D., Joanna E. Ph.D., Adele Ph.D., Anthony J. MBBS, FRCOG, Kay Ph.D., Amir Ali Ph.D., Karen Ph.D., Helen Ph.D.,