| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3932234 | Fertility and Sterility | 2011 | 4 Pages |
Abstract
Severe hypomethylation of the H19 imprinted control region (ICR1) in two patients with Silver-Russell syndrome (SRS) who have genital malformations has encouraged us to study DNA methylation in a cohort of 83 patients with Müllerian aplasia (MA). Site-specific methylation analyses of H19 ICR1 by quantitative real-time polymerase chain reaction in 80 clinically well-diagnosed Finnish MA patients showed no association between hypomethylation and the MA phenotype, but studies of the H19 locus in 38 patients showed aberrant methylation in 3/16 studied sites.
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Authors
Maria Sandbacka, Sara Bruce, Mervi Halttunen, Minna Puhakka, Päivi Lahermo, Katariina Hannula-Jouppi, Marita Lipsanen-Nyman, Juha Kere, Kristiina Aittomäki, Hannele Laivuori,