Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3932848 | Fertility and Sterility | 2010 | 6 Pages |
ObjectiveTo determine the possible relationship between serum antimüllerian hormone (AMH) concentrations on day 3 and controlled ovarian stimulation and reproductive outcomes in women with polycystic ovary syndrome.DesignProspective, clinical trial.SettingUniversity hospital.Patient(s)Sixty women with PCOS.Intervention(s)Serum concentrations of AMH measured on cycle day 3.Main Outcome Measure(s)Clinic pregnancy rate (CPR), implantation rate (IR), and fertilization rate (FR).Result(s)The CPR, IR, and FR were markedly different among the day-3 serum AMH groups (low, moderate, and high AMH groups). The CPR were 33.3, 46.1, and 60.0, respectively, in the low, moderate, and high serum AMH groups on day 3. The embryo IR were 18.6, 26.7, and 36.3, respectively. The FR were 54, 68, and 79, respectively. An AMH level ≥3.01 ng/mL was shown to predict FR with a sensitivity of 86.4% and specificity of 75%. An AMH level ≥3.2 ng/mL was shown to predict IR and CPR with sensitivity and specificity of 72.1% and 72.7%, and 75.6% and 77.3%, respectively.Conclusion(s)On day 3 of the in vitro fertilization stimulation cycle, serum concentrations of AMH can be used as a marker for ovarian response as well as reproductive outcome in assisted reproductive cycles of PCOS patients.