Severe ovarian hyperstimulation syndrome after gonadotropin-releasing hormone (GnRH) agonist trigger and “freeze-all” approach in GnRH antagonist protocol

ObjectiveTo report two cases with GnRH agonist triggering and a freeze-all approach in a GnRH antagonist protocol resulting in the development of severe ovarian hyperstimulation syndrome (OHSS), requiring hospitalization and peritoneal drainage.DesignTwo case reports.SettingA tertiary referral center and an obstetrics and gynecology department of a hospital.Patient(s)Case 1 and case 2: severe OHSS with abdominal distension, ascites development, and hemoconcentration.Intervention(s)Case 1 and case 2: diagnosed by clinical, hematologic, and ultrasound findings. Hospitalization, IV infusion, and peritoneal drainage.Main Outcome Measure(s)Symptomatic treatment and prevention of further complication.Result(s)Complete recovery.Conclusion(s)Two cases of severe OHSS after GnRH agonist trigger in a GnRH antagonist protocol without the administration of any hCG for luteal-phase support. Clinicians have to be aware that even the sequential approach to ovarian stimulation with a freeze-all attitude does not completely eliminate OHSS in all patients.