Article ID Journal Published Year Pages File Type
3935516 Fertility and Sterility 2007 7 Pages PDF
Abstract

ObjectiveTo investigate the damage of endometrium caused by the implanted Cu/low-density polyethylene (LDPE) nanocomposite and the contraceptive effect of this novel copper-containing intrauterine device material.DesignExperimental animal study.SettingTongJi Medical College of Huazhong University of Science and Technology.Patient(s)Sixty healthy female mice.Intervention(s)Twenty mice received no implants, 20 mice received the Cu/LDPE nanocomposite, and 20 mice received bulk copper.Main Outcome Measure(s)Morphologic features of the endometrium, contraceptive effect, and surface condition of the implanted implants.Result(s)The contraceptive effect of both the Cu/LDPE nanocomposite and bulk copper is 100%, the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper, and the surface of the implanted Cu/LDPE nanocomposite is much smoother and much softer than that of the implanted bulk copper.Conclusion(s)The contraceptive effect of the Cu/LDPE nanocomposite is comparable with that of bulk copper, and the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper. The endometrium injury is related to the surface condition of the implanted intrauterine device material.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
Authors
, , , , ,