Differential expression of selected gene products in uterine leiomyomata and adenomyosis

Gene products estrogen receptor α, progesteron receptor-A, retinoid X receptor α, insulin-like growth factor-II, insulin-like growth factor I receptor β, platelet-derived growth factor, epithelial growth factor receptor, and BCL-2 were examined by immunohistochemistry with the aid of a tissue microarray from 46 hysterectomies with adenomyosis and leiomyomata. With appropriate internal controls, there were significant differences in gene expression between adenomyosis and leiomyomata.