Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3936410 | Fertility and Sterility | 2009 | 6 Pages |
ObjectiveTo investigate the clinical relevance of endometriosis-associated nerve fibers in the development of endometriosis-associated symptoms.DesignProspective nonrandomized study.SettingUniversity hospital endometriosis center.Patient(s)Fifty-one premenopausal patients underwent surgical laparoscopy because of chronic pelvic pain, dysmenorrhea, or for ovarian cysts. Endometriosis was diagnosed in 44 patients.Intervention(s)The preoperative and postoperative pain scores were determined using a standardized questionnaire with a visual analogue scale from 1–10. Patients with peritoneal endometriosis were divided into two groups depending on their preoperative pain score: group A with a pain score of at least 3 or more and group B with a pain score of 2 or less. Patients without peritoneal endometriosis were classified as group C and patients without endometriosis were classified as group D. Immunohistochemical analysis of neurofilament and protein gene product 9.5 were used for nerve fiber detection. Occurrence of endometriosis-associated nerve fibers was correlated with the severity of pelvic pain and/or dysmenorrhea.Result(s)Peritoneal endometriosis-associated nerve fibers were found significantly more frequently in group A than in group B (82.6% vs. 33.3%).Conclusion(s)The present study suggests that the presence of endometriosis-associated nerve fibers in the peritoneum is important for the development of endometriosis-associated pelvic pain and dysmenorrhea.