| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3937200 | Fertility and Sterility | 2008 | 6 Pages |
ObjectiveTo determine whether polycystic ovary syndrome (PCOS) adversely impacts IVF–embryo transfer outcomes in obese compared to lean patients.DesignRetrospective chart review.SettingUniversity-affiliated infertility program.Patient(s)Lean non-PCOS (n = 52), lean PCOS (n = 6), obese non-PCOS (n = 18), and obese PCOS (n = 10).Intervention(s)Ninety-four fresh nondonor IVF–embryo transfer cycles analyzed.Main Outcome Measure(s)Cycle characteristics, clinical pregnancy (PR) and live birth rates.Result(s)Lean PCOS had more dominant follicles (12.2 ± 6.0 vs. 7.7 ± 3.6), retrieved oocytes (22.2 ± 9.2 vs. 12.6 ± 5.8), and frozen embryos (5 ± 4.6 vs. 1.4 ± 2.6) than lean non-PCOS. Lean PCOS also used fewer gonadotropin ampules (18.8 ± 6.0 vs. 29.2 ± 14.2), but had more retrieved oocytes (22.2 ± 9.2 vs.14.3 ± 4.9) than obese PCOS. Obese non-PCOS had better-grade embryos (2.1 ± 0.8 vs. 2.7 ± 0.8) and fewer embryos transferred (2.4 ± 0.6 vs. 2.9 ± 0.6) than obese PCOS, but more embryos frozen than lean non-PCOS (3.2 ± 3.2 vs. 1.4 ± 2.6). Implantation rates trended downward in obese patients with PCOS, but no other differences were observed.Conclusion(s)Patients with PCOS with a body mass index (BMI) in the lean rather than the obese range have more favorable assisted reproductive technology (ART) cycle characteristics but show no clinical outcome differences.
