Infertility and abnormal cervical mucus in two sisters who are compound heterozygotes for the cystic fibrosis (CF) ΔF508 and R117H/7T mutations

This is the first reported case of infertility due to a cervical mucus factor in a patient who is a compound heterozygote of the ΔF508 and R117H/7T mutations. This case is important not only because of the distinct phenotypic abnormality seen with specific CF mutations but also because of the associated genotype.