| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3937402 | Fertility and Sterility | 2008 | 4 Pages |
Abstract
IGF-1 levels increased, and IGF-2 and IGFBP-3 levels remained unchanged, in postmenopausal women following oophorectomy. The increase in IGF-1 likely results from decreased ovarian steroidogenic precursors resulting from removal of the hormonally active ovary. This finding raises concerns, given the association between increased IGF-1 and elevated colon cancer risk, and adds to the literature suggesting a potential benefit from ovarian preservation.
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Authors
Robin H. Fogle, Lilly Chang, Sherfaraz K. Patel, Frank Z. Stanczyk, Richard J. Paulson,