Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3937465 | Fertility and Sterility | 2012 | 7 Pages |
ObjectiveTo evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd−M) and daughters of women who belong to a healthy comparison group (HCd).DesignDescriptive and analytic study.SettingUnit of endocrinology and reproductive medicine.Patient(s)Fifteen PCOSd+M, 23 PCOSd−M, and 35 HCd were studied at 2–3 months of age.Intervention(s)A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-Müllerian hormone (AMH).Main Outcome Measure(s)Differences in AMH levels between PCOSd+M, PCOSd−M and HCd.Result(s)AMH and peak E2 concentrations were significantly higher in PCOSd−M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E2 levels similar to those observed in HCd.Conclusion(s)The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.