Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3937500 | Fertility and Sterility | 2007 | 10 Pages |
Abstract
The combination of PHI-443 and stampidine was noncytotoxic to vaginal epithelial cells, nonirritating to vaginal mucosa, and did not induce the secretion of proinflammatory cytokines and chemokines by co-cultures of human genital epithelia and Langerhans cells. These attributes are particularly useful for the clinical development of PHI-443 and stampidine as a combination microbicide and as a prophylactic anti-HIV agent to curb genital transmission of HIV-1 by semen.
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Authors
Osmond J. Ph.D., Fatih M. M.D., Ph.D.,