Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3937963 | Fertility and Sterility | 2011 | 4 Pages |
Abstract
Twenty-three-chromosome microarray analysis for aneuploidy detection and single-gene evaluation via specific DNA sequencing and linkage analysis are used for preimplantation diagnosis for single-gene disorders and aneuploidy. Because of the minimal amount of genetic material obtained from the day 3 to 5 embryos (up to 6 pg), these modalities have been used in isolation of each other. The use of preimplantation genetic diagnosis for aneuploidy coupled with testing for single-gene disorders via trophectoderm biopsy is a novel approach to maximize pregnancy outcomes. Although further investigation is warranted, preimplantation genetic diagnosis for aneuploidy and single-gene testing seem destined to be used increasingly to optimize ultimate pregnancy success.
Keywords
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Authors
Paul R. M.D., M.B.A., Andrew M.S., Svetlana Ph.D., Anver Ph.D., Ekaterina Ph.D., Dana M.S., C.G.C., William G. Ph.D.,