| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3940571 | Fertility and Sterility | 2006 | 5 Pages |
ObjectiveTo evaluate and compare the inflammatory response and mediators in the endometrium of patients with hydrosalpinges compared with normal controls.DesignRetrospective case-control study.SettingUrban medical center.Patient(s) and Intervention(s)Hysterectomy samples were identified as being affected by hydrosalpinx or salpingitis (n = 30) and were age-matched with control samples (n = 30).InterventionsFallopian tube and endometrial slides were analyzed for leukocytes and immunohistochemical techniques performed for cytokines (interleukin-2 [IL-2]).Main Outcome Measure(s)Evaluate and compare the endometrial inflammatory response (leukocytes and cytokines) from samples affected and non-affected by hydrosalpinx and salpingitis.Result(s)Examination of tubal and endometrial slides with hydrosalpinx demonstrated a statistically significant increase in the number of overall inflammatory cells. High-intensity immunohistochemical staining for IL-2 was demonstrated in 7.4% of controls versus 65% of cases.Conclusion(s)A defined, identifiable, local response to hydrosalpingeal fluid has been demonstrated in the endometrium. This response consists of statistically significant elevations of leukocytes and IL-2. An inflammatory endometrial response may be an independent contributor to the decreased reproductive outcome observed in patients with hydrosalpinges.
