Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3940577 | Fertility and Sterility | 2006 | 5 Pages |
Abstract
With regard to published cases of whole-arm translocation of human chromosome 1 with an acrocentric p arm and a maternal origin of these abnormalities, we argue for an impairment of meiosis resulting in a high probability of quadrivalent-XY-body interaction. Male factor infertility might be due to two poor prognostic factors, first the involvement of human chromosome 1 (and its heterochromatic region) and second the involvement of an acrocentric chromosome p-arm breakpoint. This probable interaction between the pachytene quadrivalent and XY body might explain azoospermia.
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Authors
François M.D., Marc M.D., Valérie M.D., Jean-Louis M.D., Jacqueline M.D., Ph.D., Marie-France M.D.,