Effect of ovarian hormones on serum adiponectin and resistin concentrations

ObjectiveTo investigate the effect of ovarian hormones on adiponectin and resistin levels in women.DesignExperimental study.SettingUniversity hospital.Patient(s)Thirteen normally cycling women (7 in group 1 and 6 in group 2) and 8 postmenopausal women (group 3).Intervention(s)Women of group 1 were investigated in a control cycle and in a subsequent cycle in which total abdominal hysterectomy plus bilateral salpingooophorectomy (TAH+BSO) was performed on day 3. In both cycles, the women received increasing doses of E2 from days 3 to 5. Women of group 2 underwent TAH+BSO on day 3 without receiving any hormonal treatment. Women of group 3 received increasing doses of E2 for 15 days.Main Outcome Measure(s)Adiponectin, resistin, and E2 concentrations.Result(s)In group 1, serum adiponectin and resistin levels did not show any significant changes for the week following day 3 and were similar in the two cycles. In group 2, adiponectin and resistin levels were similar before and after TAH+BSO and remained stable during the first postoperative week. In group 3, no significant changes in adiponectin and resistin levels were seen during the 15 days of E2 administration.Conclusion(s)Adiponectin and resistin values were not affected either by estrogen treatment or after ovariectomy in women. It is suggested that ovarian hormones are not involved in the regulation of adiponectin and resistin secretion in women.