Efficiency of changing the embryo transfer time from day 3 to day 2 among women with poor ovarian response: A prospective randomized trial

ObjectiveTo compare the outcome of day 2 and day 3 embryo transfers in women demonstrating poor ovarian response.DesignProspective randomized clinical trial.SettingPrivate assisted reproductive technology center.Patient(s)Two hundred eighty-one women demonstrating poor ovarian response to controlled ovarian hyperstimulation.Intervention(s)Women who were poor responders were randomly allocated to day 2 or day 3 embryo transfer following oocyte retrieval.Main Outcome Measure(s)Implantation rates and pregnancy rates per oocyte retrieval and embryo transfer.Result(s)The clinical pregnancy rates per oocyte retrieval (37.2% vs. 21.4%, respectively; P<.05) and per embryo transfer (38.9% vs. 24.1%, respectively; P<.05) were significantly higher in the day 2 embryo transfer group compared with day 3. On the other hand, implantation rates were not different between groups (23.9% vs. 17.2%, respectively; P=.08).Conclusion(s)Our results demonstrated that transfering embryos on day 2 could provide an alternative to the management of poor responder patients.