Article ID Journal Published Year Pages File Type
3941509 Fertility and Sterility 2009 6 Pages PDF
Abstract

Dynamic changes in configuration of germinal vesicle (GV) chromatin and their effects on oocyte transcriptional activity and developmental competence were studied in rabbit oocytes. The results indicated that global condensation of GV chromatin, rather than the formation of a perinucleolar ring, would better reflect the global transcriptional repression and developmental competence of oocytes. Gonadotropins, by promoting large-scale chromatin remodeling, regulate oocyte transcriptional activity and developmental competence.

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Dynamic changes of germinal vesicle chromatin configuration and transcriptional activity during maturation of rabbit follicles
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