Article ID Journal Published Year Pages File Type
3941617 Fertility and Sterility 2008 4 Pages PDF
Abstract

ObjectiveTo investigate the spontaneous variation of leukocytospermia (>1 million/mL) in semen samples from infertile men.DesignProspective cohort study.SettingAndrologic clinic at university hospital.Patient(s)Ninety-nine men evaluating for infertility causes.Intervention(s)Two semen analyses according the World Health Organization criteria combined with urologic investigation without any treatment.Main Outcome measure(s)Spontaneous (downward/upward) variation in leukocyte count, sperm concentration, total motility, and morphology between the two semen samples.Result(s)In the first semen analysis, 21% of men had leukocytospermia. By the second analysis, leukocyte concentrations were within the normal range in 9 of these 21 men, corresponding to a downward variation of 43%. In contrast, 7 of 78 patients with normal leukocyte levels at the first analysis had leukocytospermia at the second analysis, corresponding to an upward variation of 9%. The upward variation rates for sperm concentration, total motility, and morphology were 4%, 17%, and 4%, respectively. Downward variation rates were considerably higher for total motility and morphology (30% and 28%, respectively).Conclusion(s)The rate for spontaneous downward variation of leukocytospermia in the absence of treatment was 43% in this study. This rate should be taken into consideration when treating infertile men with leukocytospermia, because effective medical therapy is still lacking.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
Authors
, , , , ,