Article ID Journal Published Year Pages File Type
3942253 Fertility and Sterility 2006 8 Pages PDF
Abstract

ObjectiveTo examine the conception rate after cessation of a combination of 30 μg ethinyl E2 and 2 mg dienogest (EE/DNG).DesignProspective observational study.SettingPopulation-based cohort in Germany.Patient(s)Women who wished to become pregnant after cessation of an oral contraceptive (EE/DNG).Intervention(s)None.Main Outcome Measure(s)Cumulative conception rate within 1 year after termination of EE/DNG and time to pregnancy.Result(s)After 1 year of follow-up, the cumulative pregnancy rate was 86.6% (full analysis set; n = 706). When all participants with complete data were analyzed (n = 652), the cumulative pregnancy rate was 94.0%. More than 15% of the patients conceived in each of the first three cycles after termination of EE/DNG; the mean time to pregnancy was 3.5 cycles. The preceding duration of treatment with EE/DNG did not influence the conception rate. Except in the youngest age group (16–18 years), a certain delay was observed in the other age groups.Conclusion(s)The present prospective study revealed only a slight delay in regaining fertility during the first three cycles after cessation of EE/DNG. Thereafter, the cumulative rate of conception did not differ from that observed in fertile women who attempted to become pregnant without prior contraception.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
Authors
, , , , ,