| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3942955 | Gynecologic Oncology | 2016 | 8 Pages |
Abstract
Homeobox (HOX) genes are a family of transcription factors that are essential regulators of development. HOX genes play important roles in normal reproductive physiology, as well as in the development and progression of serous carcinomas, the predominant and most aggressive subtype of epithelial ovarian cancer (EOC). This review discusses aberrant HOX gene expression in serous EOC and its impact on tumor development and progression. Further identification of HOX target genes may facilitate the development of novel diagnostic and therapeutic strategies to improve the prognosis of patients with serous EOC.
Keywords
CAFsFGF-2TTRPcGDnmtCXCL12CA-125TCGASeroushomeoboxH3K27EGFRHOXEOCTAMsPBXSEREXCCL17MEIScancer antigen-125histone H3 lysine 27chemokine (C-X-C motif) ligand 12IL-10IL-6CCL2DFSTGF-β2SNPsRFSVEGFABcl-2DNA methyltransferaseOSEPFsThe cancer genome atlasOvarian surface epitheliumInterleukin-10interleukin-6progression-free survivaldisease-free survivaloverall survivalovarianTumor associated macrophagestime to recurrencerelapse-free survivalCancerEpithelial ovarian cancerVascular endothelial growth factor Abasic fibroblast growth factorCancer-associated fibroblastsB-cell lymphoma 2Genome-wide association studiesGWASnot significanthazard ratioodds ratioProteinSingle nucleotide polymorphismsGenechemokine (C-C motif) ligand 2polycomb groupEpidermal growth factor receptor
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Authors
Katherine R. Miller, Jai N. Patel, Mahrukh K. Ganapathi, David L. Tait, Ram N. Ganapathi,