| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3943898 | Gynecologic Oncology | 2012 | 6 Pages |
ObjectivesThis prospective, longitudinal study investigates QoL issues and emotional distress in early stage cervical cancer (ECC) patients undergoing radical surgery (RS) and in locally advanced cervical cancer (LACC) patients triaged to chemoradiation (CT/RT) followed by RS.MethodsThe Global Health Status scale of EORTC QLQ-C30 (GHS), the EORTC QLQ-CX24 (CX24) and the Hospital Anxiety and Depression Scale (HADS) questionnaire were administered at baseline, and after 3, 6, and 12 months from surgery. For LACC patients QoL assessment was also performed after CT/RT. Statistical analysis was performed by the ANOVA for repeated measures and the Between Subject test.ResultsIn ECC and LACC patients, the GHS scores improved over time (5.5% difference in mean scores compared to baseline in ECC, and 7.0% difference in mean score compared to baseline in LACC patients). An early worsening of lymphedema scores was documented in ECC cases (14.6% difference in mean values compared to baseline, p value = 0.001), and in LACC patients (difference up to 28.3% of mean values, value = 0.0001). Menopausal symptoms persistently worsened over time reaching > 15% difference of mean values compared to baseline in both groups. Sexual activity scores markedly improved both in ECC and LACC patients (difference of mean score values compared to baseline was 16.5% in ECC, and 6.7% in LACC patients). Both ECC and LACC patients experienced an improvement of anxiety scores.ConclusionsLymphedema and menopausal symptoms were the most disabling treatment-related sequelae; the amount of QoL issues and their multifaceted aspects require the cooperation of multidisciplinary teams.
► Global Health Scores (EORTC QLQ-C30) and anxiety improve over time in cervical cancer patients enrolled in a prospective, longitudinal study. ► Lymphedema and menopausal symptoms (EORTC QLQ-CX24) are the most disabling treatment-related sequelae, while sexual activity scores improved over time. ► The lack of association between independent variables and QoL in multivariate analysis underlines patients' capability to rescue QoL over time.
