MMP-7 (− 181A > G) promoter polymorphisms and risk for cervical cancer

ObjectivesMatrix metalloproteinase (MMP-7) is a secreted matrilysin, which contributes to tumor progression through breakdown of basement membranes and angiogenesis. Therefore, we aimed to investigate the association of MMP-7 − 181A > G gene polymorphism with risk of cervical cancer.MethodsIn the present case control study, we enrolled a total of 150 cervical cancer patients confirmed by histopathology and 162 unrelated healthy individuals. Polymorphism for MMP-7 gene (− 181A > G) was genotyped by polymerase chain reaction and restriction enzyme length polymorphism.ResultsFrequency of MMP-7 − 181GG genotype and − 181G allele differed significantly between patients with cervical cancer (29.3%) and healthy individuals (19.4%) (P = 0.041; ORGG = 1.94 and P = 0.048; ORG = 1.94). Individuals with MMP-7 − 181GG genotype were at higher risk of stage II of cervical cancer with borderline significance (P = 0.05, OR = 2.78; 95%CI: 0.89–8.69). However, interaction of MMP-7 − 181AG and GG genotypes with tobacco usage did not modulate the cervical cancer risk significantly (OR 2.21, 95%CI = 0.59–8.1 and OR 3.17, 95%CI = 0.64–15.7).ConclusionIndividuals with MMP-7 − 181GG genotype were at significantly higher risk of cervical cancer.