Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3947013 | Gynecologic Oncology | 2012 | 8 Pages |
Abstract
Cervical cancer is the second most common cancer in females worldwide. It is well-established that Human Papillomavirus (HPV) infections play a critical role in the development of cervical cancer. However, a large number of women infected with oncogenic HPV types will never develop cervical cancer. Thus, there are several external environment and genetic factors involved in the progression of a precancerous lesion to invasive cancer. In this review article, we addressed possible susceptible phenotypes to cervical cancer, focusing on host genome and HPV DNA variability, multiple HPV infections, co-infection with other agents, circulating HPV DNA and lifestyle.
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Authors
Antonio Carlos de Freitas, Ana Pavla Almeida Diniz Gurgel, Bárbara Simas Chagas, Eliane Campos Coimbra, Carolina Maria Medeiros do Amaral,