Article ID Journal Published Year Pages File Type
3950338 International Journal of Gynecology & Obstetrics 2008 4 Pages PDF
Abstract

ObjectivesTo identify the adverse effect of psychiatric illness during pregnancy on pregnancy outcome.MethodsA large population-based study of deliveries (1988–2005) was conducted that compared women with and without psychiatric illness. Stratified analysis included multiple logistic regression models.ResultsOut of 181,479 deliveries, 607 (0.3%) women reported psychiatric illness: depressive and anxiety disorders (39%), schizophrenia (11%), or other psychiatric illness (50%). The psychiatric patients were significantly older, with higher prevalence of diabetes and hypertensive disorders. Perinatal mortality rate, congenital malformations, low Apgar scores, and low birth weight (< 2500 g) were significantly increased. Multivariable logistic regression models determined that psychiatric illness during pregnancy is an independent risk factor for perinatal mortality (odds ratio [OR] 2.4; 95% CI, 1.5–3.7, P < 0.001) and congenital malformations (OR 1.4; 95% CI, 1.01–1.9, P = 0.03).ConclusionsPsychiatric illness is an independent risk factor for congenital malformations and perinatal mortality, and prenatal care should be adjusted accordingly.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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