Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction

ObjectiveTo analyze the effects of sildenafil citrate on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction.MethodIn this randomized, double-blind, placebo-controlled trial 22 women received a 50-mg dose of sildenafil (n = 11) or placebo (n = 11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual-response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment.ResultsBlood flow was significantly more improved in the sildenafil than in the placebo group (P < 0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment.ConclusionSildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction.