Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3953641 | International Journal of Gynecology & Obstetrics | 2011 | 5 Pages |
ObjectiveTo evaluate the outcomes of patients with stage IB1–IIA cervical adenocarcinoma treated by various modalities in order to formulate a better treatment strategy.MethodsThe impact of various treatment modalities on the prognosis of 258 patients with stage IB1–IIA cervical adenocarcinoma was investigated. The therapeutic modalities included radical surgery (n = 174); radical surgery followed by adjuvant radiation therapy (RT), such as RT alone or concurrent chemo-radiotherapy (CCRT) (n = 46); or primary RT or CCRT (n = 38).ResultsAs compared with patients in the surgery-only group, patients with 1 postoperative major risk who underwent surgery followed by RT or CCRT had a significantly higher likelihood of disease relapse (2.3-fold, P = 0.041) and disease-related death (2.9-fold, P = 0.014). The likelihood of recurrence (P = 0.32) and death (P = 0.58) did not differ between patients who underwent adjuvant RT or CCRT for 1 major risk factor and those who underwent primary RT or CCRT. By contrast, patients with more than 1 major risk factor had a higher likelihood of disease recurrence (2.9-fold, P = 0.037) and disease-related death (3.4-fold, P = 0.051) than those who underwent primary RT or CCRT.ConclusionRadical surgery is recommended for patients with stage IB1–IIA cervical adenocarcinomas without contraindications. Those with more than 1 postoperative pathologic risk factor had the worst prognosis despite adjuvant RT or CCRT.