Article ID Journal Published Year Pages File Type
3955260 International Journal of Gynecology & Obstetrics 2008 6 Pages PDF
Abstract

ObjectiveTo assess the effectiveness and safety of interventions to reduce blood loss during myomectomy.MethodsElectronic searches of the Cochrane Library, MEDLINE, and EMBASE, between 1966 and 2006 for randomized controlled trials (RCTs).ResultsWe found significant reductions in blood loss with vaginal misoprostol (weighted mean difference [WMD] − 149.00 mL, 95% confidence interval [CI] − 229.24 to − 68.76); intramyometrial vasopressin and analogues (WMD − 298.72 mL, 95% CI − 593.10 to − 4.34); intramyometrial bupivacaine plus epinephrine (WMD − 68.60 mL, 95% CI − 93.69 to − 43.51); and pericervical tourniquet (WMD − 1870.00 mL, 95% CI − 2547.16 to − 1192.84). There was no evidence of effect in blood loss with myoma enucleation by morcellation and oxytocin.ConclusionThere is limited evidence from a few RCTs that some interventions may reduce bleeding during myomectomy. There is need for adequately powered RCTs to shed more light on the effectiveness, safety, and cost of different interventions to reduce blood loss during myomectomy.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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