Article ID Journal Published Year Pages File Type
3955341 International Journal of Gynecology & Obstetrics 2007 5 Pages PDF
Abstract

ObjectiveTo determine whether further histologic assessment can be omitted after office sampling produced a nondiagnostic specimen.MethodsData were retrieved from a prospective cohort study of 913 women presenting with postmenopausal bleeding. This study was limited to women with an endometrial thickness either 5 mm or greater or that could not be measured, and in whom an endometrial biopsy performed in the office yielded nondiagnostic results.ResultsEndometrial thickness was nonreassuring or unknown in 516 women, of whom 403 (78.1%) underwent office endometrial sampling. In 66 women the amount of tissue obtained was not sufficient for pathologic characterization. Further investigation revealed an endometrial malignancy in 3 of these 66 women and atypical hyperplasia in 1.ConclusionIn women with postmenopausal bleeding and a nonreassuring transvaginal ultrasound evaluation, a nondiagnostic office endometrial sample does not rule out endometrial cancer and further endometrial sampling is advisable.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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