| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3955390 | International Journal of Gynecology & Obstetrics | 2007 | 4 Pages |
Objective:To evaluate the efficacy of vesical instillation of hyaluronic acid against recurrent urinary tract infections.Methods:Twenty women with a history of recurrent urinary tract infections each received 9 intravesical instillations of hyaluronic acid over 6 months. Their status was assessed prospectively over 47.6 weeks and compared with a retrospective review of patient charts covering 36.2 ± 6.2 weeks.Results:The total numbers of urinary tract infections were 67 before and 10 after treatment (p < 0.001). Thirteen patients (65%) were free of recurrences until the end of the study. One had a recurrence during treatment, and 6 (30%) during follow-up. The number of infections per year per patient was reduced from 4.99 ± 0.92 to 0.56 ± 0.82 (p < 0.001). In women with recurrences, time to recurrence was 178.3 ± 25.5 days, compared with 76.7 ± 24.6 days before treatment (p < 0.001).Conclusion:Intravesical instillation of hyaluronic acid is effective in preventing recurrent urinary tract infections.
