New Challenges in Detecting, Grading, and Staging Endometrial Cancer After Uterine Morcellation

Study ObjectiveTo evaluate the accuracy in diagnosing endometrial disease after uterine morcellation.DesignProspective case series.SettingUniversity medical center.PatientsFive women undergoing hysterectomy without morcellation because of benign indications and 5 women with endometrial cancer.InterventionsUterine specimens were obtained from all 10 study patients. The uteri were sent for pathologic analysis, processed, and fixed according to standard protocols. A single investigator then morcellated all 10 uteri. A single pathologist blinded to specimen group reviewed each specimen.Main ResultsThe pathologist identified endometrial cancer in 4 of 5 specimens of known cancer. The fifth specimen was interpreted as benign despite the presence of grade 1, stage IA endometrial adenocarcinoma. None of the morcellated specimens could be staged.ConclusionThe increasing use of uterine morcellation will result in new challenges for gynecologic oncologists secondary to difficulty in detection, and accurate grading and staging of endometrial cancer.