Article ID Journal Published Year Pages File Type
3957765 Journal of Minimally Invasive Gynecology 2008 4 Pages PDF
Abstract

Study ObjectiveTo assess whether levonorgestrel intrauterine system is an effective means of therapy in menorrhagia associated with myomas.DesignProspective before and after study (Canadian Task Force classification II–1).SettingTeaching and research hospital, a tertiary center.PatientsIn all, 21 premenopausal women attending our gynecology clinic because of menorrhagia associated with uterine myomas were enrolled into the study.InterventionsLevonorgestrel-releasing intrauterine system use in uterine myomas.Measurements and Main ResultsPatients with myomas greater than 4 cm were excluded. Clinical assessment tools of menstrual bleeding were measured both before (pretreatment) and 1 year after the insertion (posttreatment). A p value less than or equal to .05 was considered statistically significant for menstrual blood loss as a primary outcome and Bonferroni correction was done for secondary outcomes as 0.01. The mean age of the patients was 47.05 ± 4.9 years. At 1-year follow-up, 5 women had had a hysterectomy. Four patients were amenorrheic. The duration of menstruation and the mean endometrial thickness were decreased 1 year after insertion; these decreases were not statistically significant (p = .034 and p = .204, respectively). While the mean number of pads used daily during menstruation decreased (p = .011), the hemoglobin level was increased (p = .001). A reduction in mean uterine volume and increase in ferritin levels were observed, but these changes did not reach statistical significance (p = .050 and p = .036, respectively).ConclusionThe use of the levonorgestrel intrauterine system seems to be effective in reducing menorrhagia associated with myomas with improvement in hemoglobin levels.

Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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