Effects of Triggering Oocytes Maturation by rhCG 250 µg vs uhCG 10 000 IU on the Outcomes of IVF-ET Treatment in Chinese Population: A Cohort Study

ObjectiveTo compare the effects of recombinant hCG (rhCG) 250 µg and urinary hCG (uhCG) 10 000 IU on triggering oocyte maturation during COH/IVF-ET in Chinese women.MethodsA retrospective cohort study which included COH/IVF-ET cases at reproductive medical center of Peking University Third Hospital from March to May 2010 was performed. Analysis of covariance (ANCOVA) was taken for data analysis.ResultsThere were 318 cycles (group A) using rhCG 250 µg and 810 cycles (group B) using uhCG 10 000 IU for triggering. In IVF procedure, there were no significant differences in the number of oocyte retrieval, 2PN fertilization rate, good-quality embryo rate, embryo implantation rate and clinical pregnancy rate between the two groups. The delivery weeks, mean neonatal birth weight and live birth rates were also similar between the two groups. There was no local allergic reaction after injection or neonatal birth defect in group A.ConclusionsThe rhCG 250 μg and uhCG 10 000 IU have equal effects on triggering oocyte maturation for patients with normal ovarian function in Chinese population. rhCG may have even lower local discomfort occurrence.