Evaluation of Adiponectin, Resistin, IL-6, TNF-α in Obese and Non-obese Women with Polycystic Ovary Syndrome

ObjectiveTo evaluate possible clinical effects of adiponectin, resistin, IL-6, and TNF-α in obese and non-obese patients with polycystic ovary syndrome (PCOS).MethodsSeventy selected PCOS patients were recruited for this study, and were divided into two groups based on their body mass index (BMI): 35 obese (BMI ≥ 25 kg/m2, group A), 35 non-obese (BMI<25 kg/m2 group B). In addition, 35 healthy non-obese women (BMI<25 kg/m2) were enrolled as the control (group C). Serum levels of FSH, LH, T, glucose, insulin, adiponectin, resistin, IL-6, TNF-α were detected, and compared the differences of them among three groups.ResultsBlood glucose levels among three groups had no difference (P>0.05). Blood insulin level was significantly greater in group A than in group B or group C (P<0.05), and a significant difference existed between group B and group C (P<0.05). The ratio of glucose/insulin was significantly higher in group A than in group B or group C (P<0.05), and the ratio in group B was significantly higher than that in group C (P<0.05). Adiponectin level was significantly lower and resistin level was significantly higher in group A than in group B or group C (P<0.05). IL-6 level in group C was significantly lower than that in group A or group B (P<0.05), and significant difference was found between group A and group B (P<0.05). TNF-α level was a slight high in group B, whereas there was no statistical difference among three groups (P>0.05).ConclusionDisturbances of some metabolic and inflammatory adipokines could involve the pathogenesis of PCOS in both obese and non-obese women. Low-grade chronic inflammation might have negative effects on the development of PCOS in nonobese women.