Anti-Müllerian hormone, antral follicle count and follicle-stimulating hormone for predicting the number of oocytes retrieved in IVF/ICSI cycles

ObjectiveTo evaluate the efficacy of anti-Müllerian hormone (AMH), antral follicle count (AFC) and follicle-stimulating hormone (FSH) for predicting the number of oocytes retrieved in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles.MethodsIn this retrospective study, a total of 122 infertile women were divided into two groups: group A, <35 years (n=71); group B, ≥35 years (n=51). AMH and FSH were determined on 2-5 d of the early menstrual cycle. AFC was tested on the second day of the menstrual cycle before the start of stimulation.ResultsGroup B had higher FSH levels compared with group A (8.2±3.5 IU/L vs 6.8±2.4 IU/L, P<0.05). However, levels of AMH and AFC in group B were lower than those of group A (AMH: 4.2±3.5 μg/L vs 2.7±2.7 μg/L; AFC: 9.0±3.9 vs 5.4±3.3, P<0.05). The number of oocyte retrieved in the two groups was not significantly different (11.5±6.8 vs 9.6±6.9, P>0.05). The level of AMH was more strongly correlated with the number of oocytes retrieved than that of AFC or FSH level. The strengths of the correlation degrees were AMH level, AFC, and FSH level in turn (r=0.600, 0.511, −0.369).ConclusionAMH would be a useful predictor for ovarian response.