Circulating anti-Müllerian hormone as predictor of ovarian response to gonadotrophins in women with polycystic ovary syndrome

ObjectiveTo investigate the impact of high circulating anti-Müllerian hormone (AMH) on the outcome of ovulation induction using human menopausal gonadotropin (hMG)in women with polycystic ovary syndrome (PCOS).MethodsThis prospective study included 63 anovulatory women with PCOS who underwent hMG ovarian stimulation. Serum AMH concentrations were compared between responders and non-responders. The receiver-operating characteristic (ROC) curve was used to evaluate the prognostic value of circulating AMH.ResultshMG responders had a significantly lower serum AMH concentration compared with non-responders (8.43±2.18 μg/L vs 11.05±2.85 μg/L, P<0.001). In multivariate Logistic regression analysis, AMH was an independent predictor of ovulation induction by hMG in PCOS patients. ROC curve analysis showed AMH was a useful predictor of ovulation induction by hMG in PCOS patients, having 91.7% specificity and 66.7% sensitivity when the threshold AMH concentration was 10.12 μg/L.ConclusionSerum AMH can be used as an effective parameter to predict ovarian response to hMG treatment in PCOS patients.