Application of Ultra-low-dose Incremental Gn Protocol in Controlled Ovarian Hyperstimulation of the Patients with Ovary Hyperreaction

ObjectiveTo explore the clinical outcome of ultra-low-dose incremental protocol in the controlled ovarian hyperstimulation (COH) for the ovary hyperreaction patient.MethodsA prospective, randomized, controlled study was conducted between June 2006 and February 2008 on 120 women who underwent COH. The patients' clinic outcomes were compared between ultra-low-dose incremental protocal (experimental group, n=60) and other ovulation stimulating protocols (control group, n=60).ResultsThe mean number of large follicles (≥14 mm) on the day of oocytes retrivaling, the mean number of harvested oocytes and the incidence rate of OHSS were significantly lower in experimental group. However, the gonadotropin stimulating time was significantly longer in experimental group. And the rate of leading follicle punctuation was also higher in this group when compared with control group. The clinical pregnant rate, the mean number of gonadotropin ampoules, the cancel rate were similar in the two groups.ConclusionThe application of ultra-low-dose incremental protocal in the COH for the ovarian hyperreaction patients is able to effectively reduce the risk of occurrence of OHSS under the precondition of assurance of pregnancy rate. It is a safe and more effective COH program.