Innate immune function of the human decidual cell at the maternal–fetal interface

The aim of the study was to investigate the innate immune function of decidual cells from term unlabored pregnancies by determining Toll-like receptor presence and function.Using immunohistochemistry, reverse transcriptase polymerase chain reaction and NF-κB-luciferase plasmid transfection, Toll-like receptor presence and function was determined.Decidual cells express Toll-like receptors 1, 2, 4 and 6 which respond to lipopolysaccharide and peptidoglycan stimulation producing Interleukin-8.Decidual cells from women at term have innate immune function and are capable of producing Interleukin responses to bacterial ligands.