FAS and FAS ligand gene polymorphisms in Egyptian females with preeclampsia

We aimed to evaluate the association of Fas polymorphism and the Fas ligand with preeclampsia, investigating whether the G 670 Fas gene variant and the Fas Ligand INV2nt 124 G variant had a differential distribution in patients with preeclampsia. The preeclamptic group consisted of 50 pregnant women who developed preeclampsia, while the control group consisted of 50 age-matched pregnant women with uncomplicated pregnancies. Fas and Fas ligand gene polymorphisms were tested using polymerase chain reaction–restriction fragment length polymorphism. Regarding the Fas 670 A > G polymorphism, statistically significant differences were found between the two groups regarding the AA and GG/AG genotypes as well as the A, G allele frequency, while no statistically significant differences were found regarding AG or GG genotypes. Regarding the FasLG IVS2nt 124 A > G polymorphism, no statistically significant differences were found between the two groups studied. Concerning the Fas 670 A > G gene, no statistically significant differences between the severe and mild preeclampsia groups regarding the A allele frequency were found. Concerning the FasLG IVS2nt 124 A > G gene, there were no statistically significant differences between the severe and mild preeclampsia groups regarding the A allele frequency or the G allele frequency. The presence of the Fas gene polymorphism Fas A670G is associated with an increased risk of preeclampsia, while the presence of FasLG IVS2nt 124 A > G gene may be protective against preeclampsia.