Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3964625 | Journal of Reproductive Immunology | 2011 | 5 Pages |
Abstract
IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal–fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation.
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Authors
Satyan Kalkunte, Tania Nevers, Wendy E. Norris, Surendra Sharma,